Research Progress in Molecular Biology of Fish Immunoglobulin M (IgM)

Immunoglobulin (Ig) is a type of globulin produced by B lymphocytes during pathogenic infection vertebrates. It has immune functions and can realize specific recognition neutralization corresponding antigens. As IgM reported first in fish, the antibody responses plays vital role systemic mucosal tissues. molecules have two forms: membrane-bound (mIgM) secreted (sIgM). The latter plasmacytes into body fluid, existing as immunological effect molecules. former embeds cytomembrane exists an antigen receptor. binds with assistant to form cell receptor compounds. This study reviews research progress on structures production processes genes different fish species distribution characteristics cells, mediated signal pathways, functions. aims enrich basic theoretical knowledge immunology provide some scientific references for disease control fishes.